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YU-NO-KAI-SERIES Vita — YU-NO-KAI-SERIES is a Japanese adult visual novel developed by YU-NO-KAI and released on January 28, 2008 for the PlayStation Portable. This game is the sixth in the YU-NO-KAI-SERIES series. You can download YU-NO-KAI-SERIES Vita for free from DLSite:.Immunohistochemical evidence of aberrant thyroid hormone receptor expression in human renal carcinoma.
Thyroid hormone receptors (TR) are ligand-activated transcription factors that regulate gene expression in response to T3. The TRs have recently been implicated in the pathophysiology of breast, colon, and prostate cancer. In this study, we sought to assess the expression of TR alpha 1 and TR beta 1 protein in human primary renal cell carcinoma, and to determine the relationship between TR expression and disease outcome in these patients. The distribution of TR alpha 1, TR beta 1, and thyroid hormone receptor regulator-1 (TRR-1) protein was examined in normal renal and cell renal cortical tissues (n = 6), and in different renal cell carcinoma (RCC) cell lines (n = 3). Protein expression was examined by direct immunofluorescence and immunohistochemistry. TR expression was present in normal renal tissue, but was aberrant in RCCs. TR protein expression was confined to the nuclei of normal renal cells, but was present in the cytoplasm and/or nuclei of RCC cells in both primary (n = 3) and metastatic RCC (n = 3) tissue sections. TR alpha 1 and TR beta 1 protein expression was confined to the nuclei of all normal renal cells in the tissues examined, but was aberrant in RCC cells. TR beta 1 staining was also observed in the nuclei of interstitial renal cells in tissues from patients with non-malignant renal disease. Aberrant TR protein expression was seen in both clear cell and non-clear cell carcinomas. Nuclear TR alpha 1 and TR beta 1 expression was related to tumor histopathology,
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